代表性论文 |
研究聚焦农业动物重要经济性状的功能多组学,基于基因组、单细胞转录组、空间转录组等大数据分析,揭示不同群体遗传差异,深入探讨群体基因组的进化过程、表型变异以及适应性进化,致力于农业育种创新。 代表成果一:揭示自然选择和人工选择对动物表型的塑造及关键变异,在联合国粮农组织发布的政策文件、国际著名期刊中被多次引用。 Deng J, Xie XL, Wang DF, Zhao C, Lv FH, Li X, Yang J, Yu JL, Shen M, Gao L, Yang JQ, Liu MJ, Li WR, Wang YT, Wang F, Li JQ, Hehua E, Liu YG, Shen ZQ, Ren YL, Liu GJ, Chen ZH, Gorkhali NA, Rushdi HE, Salehian-Dehkordi H, Esmailizadeh A, Nosrati M, Paiva SR, Caetano AR, Štěpánek O, Olsaker I, Weimann C, Erhardt G, Curik I, Kantanen J, Mwacharo JM, Hanotte O, Bruford MW, Ciani E, Periasamy K, Amills M, Lenstra JA, Han JL, Zhang HP, Li L, and Li MH. Paternal Origins and Migratory Episodes of Domestic Sheep. Current Biology, 2020, 30, 4085–4095 e6.(中科院1区,自然指数期刊,IF=10.834) 代表成果二:首次在单细胞分辨率下,绘制从胚胎到体成熟关键发育阶段的消化道单细胞图谱,跨物种解析消化道关键调控因子的保守和特异性,提供农业动物性状形成的重要遗传资源。 Deng J, Liu YJ, Wei WT, Huang QX, Zhao LP, Luo LY, Yu JL, Zhu Q, Zhang L, Chen Y, Ren YL, Jia SG, Lin YL, Yang J, Lv FH, Zhang HP, Li FE, Li L*, and Li MH*. Single-cell transcriptome and metagenome profiling reveal the genetic basis of rumen functions and convergent developmental patterns between ruminants. Genome Research. 2023, 33: 1690-1707.(中科院1区, 自然指数期刊, IF= 9.438) 其它相关研究成果: [1] Li X, He S G, Li W R, Luo L Y, Yan Z, Mo D X, Wan X, Lv F H, Yang J, Xu Y X, Deng J, Zhu Q H, Xie X L, Xu S S, Liu C X, Peng X R, Han B, Li Z H,Chen L, Han J L, Ding X Z, Dingkao R, Chu Y F, Wu J Y, Wang L M, Zhou P, Liu M J, and Li M H. Genomic analyses of Pamir argali, Tibetan sheep, and their hybrids provide insights into chromosome evolution, phenotypic variation, and germplasm innovation. Genome Research 2022, 32(9):1669-1684. (中科院1区, 自然指数期刊, IF= 11.093) [2] Li X, Yang J, Shen M, Xie X L, Liu G J, Xu Y X, Lv F H, Yang H, Yang Y L, Liu C B, Zhou P, Wan P C, Zhang Y S, Gao L, Yang J Q, Pi W H, Ren Y L, Shen Z Q, Wang F, Deng J, Xu S S, Salehian-Dehkordi H, Hehua E, Esmailizadeh A, Dehghani-Qanatqestani M, Tpnek O, Weimann C, Erhardt G, Amane A, Mwacharo J M, Han J L, Hanotte O, Lenstra J A, Kantanen J, Coltman D W, Kijas J W, Bruford M W, Periasamy K, Wang X H, and Li M H. Whole-genome resequencing of wild and domestic sheep identifies genes associated with morphological and agronomic traits. Nature Communications. 2020, 11: 2815. (中科院1区, 自然指数期刊, IF= 14.920) [3] Deng J#, Feng J#, Li L, Zhong T, Wang LJ, Guo JZ, Ba G, Song TZ, and Zhang HP*. Polymorphisms, differentiation, and phylogeny of 10 Tibetan goat populations inferred from mitochondrial D-loop sequences. Mitochondrial DNA Part A, 2018, 29, 439–445.(SCI) [4] 邓娟, 张红平, 巴贵, 次仁德吉, 宋天增*, 李 利*. 基于Cytb基因多态性研究西藏地区8个藏山羊群体遗传结构及母系起源[J]. 畜牧兽医学报, 2018, 49(1): 65–74.(CSCD) [5] 邓娟, 张红平, 宋天增*, 李 利*.基于线粒体ATP6及Cytb基因多态性研究藏山羊高原适应性.畜牧兽医学报, 2020, 51(7): 1573–1586.(CSCD) |